Molecular basis of magnetic resonance imaging
Contrast in magnetic resonance images of soft tissue is largely governed by the spin relaxation properties of water protons. We study tissue models and develop relaxation theory to unravel the mechanisms resposible for image contrast.
Legend: Water 1H MRD profiles (left) from immobilized ubiquitin in protonated (red solid circles) or 83% deuterated (open blue circles) forms, demonstrating that the dominant relaxation mechanism is exchange-mediated orientational randomization (EMOR) of labile hydrogens rather than collective vibrations of backbone protons (spin fracton model).The protein structure (right) shows the H (red) and D (blue) atoms in partially deuterated ubiquitin, as well as the labile hydroxyl protons (yellow) responsible for the low-frequency relaxation dispersion.
E P Sunde & B Halle, JACS 131, 18214–18215 (2009).
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