MPS seminar Sergei Vinogradov

Prof. Sergei Vinogradov, Dept of Biochemistry and Biophysics, University of Pennsylvania, USA.
"Seeing Oxygen by Phosphorescence: New Developments in Chemistry, Microscopy and Tomography."
Homepage Sergei Vinogradov

Host: Cecilia Hägerhäll

Abstract:
Oxygen is a key metabolite and a useful marker of tissue physiological status. Quantitative imaging of oxygen levels in tissue can be accomplished using oxygen dependent quenching of phosphorescence. When exogenous phosphorescent probes are dissolved in the blood or in the interstitial space, their emission lifetimes can serve as sensitive and selective indicators of tissue oxygenation. Dendrimers with near infra-red absorbing porphyrins as cores have been developed and utilized in tomography and multiphoton microscopy of oxygen. Chemistry of the probes and some aspects of the phosphorescence quenching technology will be discussed in the context of in vivo oxygen imaging application.

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