The calcium ion is a ubiquitous second messenger involved in the regulation of a vast number of cellular and extracellular activities in the body, including memory and learning. We investigate the interactions of calcium signaling proteins with target proteins and metal ions. We identify novel targets and quantify their binding parameters and functional effects. Particular emphasis is on calmodulin and the two hexa-EF-hand proteins secretagogin and calbindin D28k. We have recently discovered a large set of novel targets of human calmodulin, and of particular interest is the finding of a large number of transmembrane proteins. For secretagogin we have discovered a number of vesicle-associated target proteins, and for calbindin an enzyme involved in phospho-inositol signaling.

Link to CaLigator software