Akke Research Group

Group members

• Anna Bille, PhD student
• Carl Diehl, postdoc
• Michal Respondek, postdoc
• Gleb Solomentsev, postdoc
• Ulrich Weininger, postdoc
• Kristofer Modig, lecturer

Recent publications

Protein flexibility and conformational entropy in ligand design targeting the carbohydrate recognition motif of galectin-3. Diehl C, Engström O, Delaine T, Håkansson M, Genheden S, Modig K, Leffler H, Ryde U, Nilsson UJ, Akke M. J. Am. Chem. Soc. 132, 14577-14589 (2010). 

Structure and dynamics of ribosomal protein L12: an ensemble model based on SAXS and NMR relaxation. Bernado P, Modig K, Grela P, Svergun D, Tchorzewski M, Pons M, Akke M. Biophys. J. 98, 2374-2382 (2010). 

Transient structural distortion of metal-free Cu/Zn superoxide dismutase triggers aberrant oligomerization. Teilum K, Smith MH, Schultz E, Christensen LC, Solomentsev G, Oliveberg M, Akke M. Proc. Natl. Acad. Sci. U.S.A. 106, 18273-18278 (2009).

Conformational entropy changes upon lactose binding to the carbohydrate recognition domain of galectin-3. Diehl C, Genheden S, Modig K, Ryde U, Akke M.  J. Biomol. NMR 45, 157–169 (2009).

Differential response of the backbone and side chain conformational dynamics in FKBP12 upon binding the transition state analog FK506: Implications for transition state stabilization and target protein recognition. Brath U, Akke M. J. Mol. Biol. 387, 233–244 (2009).

Multiple timescale dynamics of side-chain carboxyl and carbonyl groups in proteins by ¹³C spin relaxation. Paquin R, Ferrage F, Mulder FAA, Akke M, Bodenhausen G.  J. Am. Chem. Soc. 130, 15805–15807 (2008).

Characterization of Chemical Exchange Using Residual Dipolar Coupling. Igumenova TI, Brath U, Akke M, Palmer AG.  J. Am. Chem. Soc. 129, 13396–13397 (2007).

Fractional ¹³C enrichment of isolated carbons using [1-¹³C]- or [2-¹³C]-glucose facilitates the accurate measurement of dynamics at backbone Cα and side-chain methyl positions in protein. Lundström P, Teilum K, Carstensen T, Bezsonova I, Wiesner S, Hansen F, Religa TL, Akke M, Kay LE. J. Biomol. NMR 38, 199-212 (2007).

The ribosomal stalk binds to translation factors IF2, EF-Tu, EF-G, and RF3 via a conserved region of the L12 C-terminal domain. Helgstrand M, Mandava CS, Mulder FAA, Liljas A, Sanyal S, Akke M. J. Mol. Biol. 365, 468-479 (2007).

Structural characterization of the ribosomal P1A-P2B protein dimer by small-angle X-ray scattering and NMR spectroscopy. Grela P, Helgstrand M, Krokowski D, Svergun D, Liljas A, Bernadó P, Grankowski N, Akke M, Tchorzewski M. Biochemistry 46, 1988-1998 (2007).

 

 

Current projects

Conformational entropy in ligand binding and drug design

Conformational dynamics and enzyme catalysis

Partial unfolding and transient oligomerization of superoxide dismutase

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